Hormonal Changes
Hormonal changes have a role in the progression of atopic dermatitis. Hormone fluctuation can trigger this condition, especially in females. Progesterone and estrogen are the hormones responsible for menstruation and for producing multiple responses in tissues and organs. The human body has several estrogen and progesterone receptors, and they have multiple roles, including pigmentation of the skin. A drop in estrogen level due to the premenstrual period affects the skin, causing more water loss, increase microorganisms, and decreased wound healing. This condition can exaggerate the skin affected by atopic dermatitis and can damage skin barrier reading to reduce the ability of akin to maintain its natural amount of water, excess water loss from skin result in skin dryness and allow allergens and germs to infiltrate the skin. This hormonal decline can be seen through the skin, and it triggers atopic dermatitis. If a person is already suffering from atopic dermatitis, then it makes the condition worse. Hormonal replacement therapy can help in minimizing the effects and help in improving the skin condition.