Top Causes Of Amyloidosis
Anyone can develop amyloidosis, but the main reason for the development of this disease is a genetic mutation. The changes in the protein structures due to gene mutations make them insoluble. These insoluble proteins start depositing in the spaces between plasma cells and cause amyloid build-up. As the gene mutations in DNA cause structural changes in protein, making them amyloid, that is the reason this disease is passing on to the next generations.
The risk factors for hereditary amyloidosis are gender, weak immunity, and previous family history of the disease. Individuals with a family history of chronic inflammatory diseases like rheumatoid arthritis, chronic peptidic ulcers, asthma, and active hepatitis are more susceptible to systematic amyloidosis.
Risk factors do not directly cause the disease but are important in the development and progression of the disease. Also, these risk factors potentially increase the probability of acquiring the disease. Amyloidosis also has some risk factors that are necessary to look for first the diagnosis and then the treatment of amyloidosis.
Most of the people who acquire amyloidosis are not aware of the risk factors, and the actual causes of the disease are also unknown. A large portion of the population with amyloidosis does not show any identified symptoms of amyloidosis, so most of them are unaware of their condition until they fall sick seriously.
As the progression is not so visible, anyone can develop amyloidosis. Following are some of the most defined and well-established risk factors for amyloidosis:
Sex:
Mostly researchers reveal that amyloidosis affects almost 70% of the male population, while females are less prone to the disease. Men being more susceptible to the disease should be more watchful about their health. Medical specialists, therefore, recommend hematological analysis at least twice a year.