Smoking
Tobacco smoking produces certain pathogenic effects in the human body, which associate with a higher risk of developing Dupuytren’s contracture. Cigarette smoking for longer times causes subsequent inflammation of muscle fibers, thus causing the stiffness of the connective tissues. The pathogenic effect of tobacco smoking produces microvascular occlusion, which leads to the deformity of the fingers. According to studies, the risk for Dupuytren’s contracture is almost three times higher in the people who smoke regularly, and the main reason is the impairment of microvascular system.