Peptic ulcer disease is a situation in which painful ulcers or sores form in the stomach lining or the first area of the small intestine (known as the duodenum). Generally, the thick layer in the mucus aids in protecting the stomach lining from the impact of its digestive juices. But various things might lower the protective layer, letting stomach acid harm the tissue. Peptic ulcer disease happens when open ulcers or sore from the stomach or the above part of the small intestine. Many peptic ulcer diseases form because infection occurs. After all, bacteria consume the protective lining present in the digestive system. People who take painkillers frequently are more likely to have ulcers.