What Are Cataracts? Definition, Symptoms, Causes, Types, Risk Factors, Diagnosing, Cataracts Surgery, Cataracts Surgery Recovery, Cataracts Surgery Cost, Cataracts Prevention

2Pathophysiology Of Cataract

Pathophysiology of cataract
Pathophysiology of cataract

The lens is made up of intricate arrays of protein fibers. These proteins are called ‘crystallins’. The arrangement of these proteins provides the lens its transparency. Chemical groups attached to these proteins also help in neutralizing the oxidative damage which may result as metabolism, UV radiation etc. With age, these proteins undergo age-related degeneration, which can result in

  • Either disruption in the architecture of proteins, leading to loss of transparency
  • Or, an inability to efficiently cope with oxidative stress, resulting in oxidative injury of lens structural units.

The proteins in the lens clump together, which may be simultaneously accompanied by the continuous introduction of new fibers from the periphery of the lens. This results in thickening of the lens, or cause the lens to become pigmented.