Jaundice
Another symptom with a very high predictive value is jaundice, but it often appears late in the development of the disease. Jaundice is the result of bilirubin being accumulated in the blood and the skin. Bilirubin is commonly eliminated in the bile, but when the bile duct has an obstruction, it starts flowing backwards until reaching the blood and entering the general circulation. This changes the colour of the skin to a yellowish tone, but it should be differentiated from the changes of skin colour experienced by people eating too many carrots and other foods with pigments called carotenoids.
Your doctor should examine jaundice, and it is a significant sign of hepatic involvement. You may need to run a series of tests to identify the magnitude of the problem. It is a common symptom in hepatitis and other viruses directly or indirectly affecting the liver. Thus, doctors should rule out these problems as a part of their diagnostic procedures.