Cancer
The abnormal and uncontrolled division of cells can give rise to cancer. The first symptom most people notice during cancer is weight loss owing to the excess energy expenditure on rapidly dividing cancer cells. Weight loss also happens in patients while going through cancer treatments. It is because chemotherapy and radiation negatively affect eating habits. Inflammation, a result of the body’s response to a tumor produces, immunoregulatory cytokines that favor inflammation and alter body metabolism. This further brings changes to appetite-controlling hormones. The tumors in the stomach, pancreas and esophagus are the most common cancers that cause weight loss.