Splenic Sequestration
Splenic sequestration is the blockage of the splenic vessels due to sickle cells. The condition causes a sudden and painful enlargement of the spleen. In severe conditions, the spleen may have to be removed because of sickle cell anemia known as a splenectomy.
Some sickle cell patients can sustain enough damage to the spleen that it becomes shrunken and ceases to function at all called auto splenectomy. The essential point to note is, patients without a spleen are at higher risk for infections.